One of our long-term goals is to recapitulate thymus function in patient-specific systems, to study the molecular basis of immune syndromes and pursue development of innovative treatment strategies. To be able to generate patient-specific thymus function, we utilize human pluripotent stem cells in directed differentiation approaches that mimic developmental differentiation cues in 2D or 3D cell culture environment.

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Stem Cell Biology Developmental Biology Immunology Functional Genomics